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Guideline Summary
Guideline Title
Analgesia and anesthesia for the breastfeeding mother, revised 2012.
Bibliographic Source(s)
Montgomery A, Hale TW, The Academy of Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2012. Breastfeed Med. 2012 Dec;7:547-53. [59 references] PubMed External Web Site Policy
Guideline Status

This is the current release of the guideline.

This guideline updates a previous version: Montgomery A, Hale TW, Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #15: analgesia and anesthesia for the breastfeeding mother. Breastfeed Med 2006 Winter;1(4):271-7. [50 references]

FDA Warning/Regulatory Alert

Note from the National Guideline Clearinghouse: This guideline references a drug(s) for which important revised regulatory and/or warning information has been released.

  • August 1, 2013 – Acetaminophen External Web Site Policy: The U.S. Food and Drug Administration (FDA) notified healthcare professionals and patients that acetaminophen has been associated with a risk of rare but serious skin reactions. Acetaminophen is a common active ingredient to treat pain and reduce fever; it is included in many prescription and over-the-counter (OTC) products. These skin reactions, known as Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP), can be fatal. These reactions can occur with first-time use of acetaminophen or at any time while it is being taken. Other drugs used to treat fever and pain/body aches (e.g., non-steroidal anti-inflammatory drugs, or NSAIDS, such as ibuprofen and naproxen) also carry the risk of causing serious skin reactions, which is already described in the warnings section of their drug labels.

Scope

Disease/Condition(s)

Conditions that require analgesia and anesthesia for the breastfeeding mother

Guideline Category
Evaluation
Management
Prevention
Risk Assessment
Treatment
Clinical Specialty
Anesthesiology
Critical Care
Dentistry
Family Practice
Internal Medicine
Nursing
Nutrition
Obstetrics and Gynecology
Pediatrics
Plastic Surgery
Surgery
Intended Users
Advanced Practice Nurses
Allied Health Personnel
Dentists
Nurses
Physician Assistants
Physicians
Guideline Objective(s)
  • To provide recommendations for safe and appropriate use of pharmacologic agents for anesthesia and pain relief in breastfeeding women during labor and postpartum and for lactating women during surgery
  • To examine the evidence currently available for various approaches to labor pain management on breastfeeding outcomes and make recommendations for prudent practice
Target Population
  • Women in childbirth labor with pain
  • Women in the postpartum period with pain
  • Breastfeeding mothers undergoing surgery
Interventions and Practices Considered
  1. Informed consent discussion on pain management
  2. Analgesia and anesthesia for labor
    • Support by doula
    • Nonpharmacologic methods (e.g., hypnosis, acupuncture)
    • Parenteral opiates (e.g., fentanyl, sufentanil)
    • Epidural analgesia, minimizing dose and motor block and providing follow-up with breastfeeding support
  3. Regional anesthesia for Cesarean section (epidural or intrathecal/spinal)
  4. Postpartum anesthesia
    • Non-opioid analgesics (e.g., acetaminophen/paracetamol, ibuprofen)
    • Parenteral medications (e.g., morphine)
    • Patient-controlled analgesia (PCA)
    • Oral medications (e.g., hydrocodone)
    • Epidural/spinal medications, including single dose opioids and continuous infusion
  5. Surgery in breastfeeding mothers
    • Regional or local anesthesia
    • Single dose of medication (e.g., fentanyl, midazolam)
    • Resumption of breastfeeding
  6. Specific agents for anesthesia and analgesia
Major Outcomes Considered
  • Pain relief
  • Adverse events in the breastfed infant associated with treatment
  • Drug levels in milk
  • Safety to initiate and continue breastfeeding

Methodology

Methods Used to Collect/Select the Evidence
Searches of Electronic Databases
Description of Methods Used to Collect/Select the Evidence

An initial search of relevant published articles written in English in the past 20 years in the fields of medicine, psychiatry, psychology, and basic biological science is undertaken for a particular topic. Once the articles are gathered, the papers are evaluated for scientific accuracy and significance.

The search was conducted primarily using PubMed. In addition, bibliographies of articles found were used to look for additional supportive articles. A search was done prior to the original protocol publication in 2005 and was repeated in January-March 2011. A search for all articles from the past 20 years (and as far back as late 1970 for some subtopics) was conducted. No specific inclusion criteria were used. Search terms included: "breastfeeding" or "lactation" or "postpartum" AND "analgesia" or "anesthesia" or "labor pain" (all appropriate combinations of those terms).

Number of Source Documents

Not stated

Methods Used to Assess the Quality and Strength of the Evidence
Expert Consensus (Committee)
Weighting According to a Rating Scheme (Scheme Given)
Rating Scheme for the Strength of the Evidence

Levels of Evidence

I Evidence obtained from at least one properly randomized controlled trial

II-1 Evidence obtained from well-designed controlled trials without randomization

II-2 Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group

II-3 Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments (such as the results of the introduction of penicillin treatment in the 1940s) could also be regarded as this type of evidence.

III Opinions of respected authorities, based on clinical experience, descriptive studies and case reports; or reports of expert committees

Methods Used to Analyze the Evidence
Systematic Review with Evidence Tables
Description of the Methods Used to Analyze the Evidence

An expert panel is identified and appointed to develop a draft protocol using evidence based methodology. An annotated bibliography (literature review), including salient gaps in the literature, are submitted by the expert panel to the Protocol Committee.

Methods Used to Formulate the Recommendations
Expert Consensus
Description of Methods Used to Formulate the Recommendations

Not stated

Rating Scheme for the Strength of the Recommendations

Not applicable

Cost Analysis

A formal cost analysis was not performed and published cost analyses were not reviewed.

Method of Guideline Validation
External Peer Review
Internal Peer Review
Description of Method of Guideline Validation

The draft protocol is peer reviewed by individuals outside of contributing author/expert panel, including specific review for international applicability. The Protocol Committee's sub-group of international experts recommends appropriate international reviewers. The Chair and/or protocol resource person institutes and facilitates this process. Reviews are submitted to the committee Chair and resource person.

The contributing author/expert panel and/or designated members of protocol committee work to amend the protocol as needed.

The draft protocol is submitted to the Academy of Breastfeeding Medicine (ABM) Board for review and approval. Comments for revision will be accepted for three weeks following submission. The Chair, resource person and protocol contributor(s) amend the protocol as needed.

Following all revisions, the protocol has the final review by original contributor(s) to make final suggestions and ascertain whether to maintain contributing authorship.

The final protocol is submitted to the Board of Directors of ABM for approval. A two-thirds majority of Board members' positive vote is required for final approval.

Recommendations

Major Recommendations

Definitions for the quality of evidence (I-III) are provided at the end of the "Major Recommendations" field.

Analgesia and Anesthesia for Labor

  1. Maternity care providers should initiate an informed consent discussion for pain management in labor during the prenatal period, well before the onset of labor. Risk discussion should include what is known about the effects of various modalities on the progress of labor, risk of instrumented and cesarean delivery, effects on the newborn, and possible breastfeeding effects. (III)
  2. Unmedicated, spontaneous vaginal birth with immediate, uninterrupted skin-to-skin contact leads to the highest likelihood of baby-led breastfeeding initiation. Longer labors, instrumented deliveries, cesarean section, and separation of mother and infant after birth may lead to higher risk of difficulty with breastfeeding initiation. Labor pain management strategies may affect these birth outcomes and secondarily affect breastfeeding initiation in addition to any direct effects of the medications themselves. (II-1; II-2)
  3. Women have differing levels of pain tolerance. Labor pain may exceed a woman's ability to cope or be magnified by fear and anxiety. Suffering in labor may lead to dysfunctional labors, poorer psychologic outcomes, and increased risk of postpartum depression, all of which may have a negative effect on breastfeeding. Severe maternal physiologic stress in labor also causes physiologic stress for babies, which may affect their readiness to breastfeed at birth. (III)
  4. Continuous support in labor, ideally by a trained doula, reduces the need for pharmacologic pain management in labor and decreases the rates of instrumented delivery and cesarean section. An earlier meta-analysis suggested that doulas also improve breastfeeding outcomes both in the immediate postpartum period and several weeks after birth, but an update to this meta-analysis did not find statistical differences in breastfeeding outcomes. (I)
  5. Nonpharmacologic methods for pain management in labor such as hypnosis and acupuncture have been found effective in reducing labor pain. (I) Other methods that are used in some but not all countries such as psychoprophylaxis (e.g., Lamaze), intradermal and/or subcutaneous water injections for back pain, etc., appear to be safe and have no known adverse neonatal effects. These methods may reduce the need for pharmacologic interventions. Additional study of breastfeeding outcomes is needed for these modalities.
  6. Evidence suggests that breastfeeding success is affected by the behavior of the newborn. Depressed or delayed suckling, which can be caused by medications given to mothers, can lead to delayed or suppressed lactogenesis and risk of excess infant weight loss. (II-2)
  7. Intrapartum intravenous fluids are often given in larger quantities when pharmacologic pain relief methods such as epidural analgesia or anesthesia are used. These fluids can potentially lead to maternal engorgement, affect birth weight and newborn weight loss, and cause neonatal hyperglycemia and rebound hyperinsulinemia. (II-2)
  8. Parenteral (intravenous, intramuscular) opiates used for labor may block the newborn's normal reflexes to suckle at the breast within the first hour after birth.
    1. If opiates are used, shorter-acting opiates such as fentanyl or sufentanil are preferred. Remifentanil is potent and has rapid onset and offset but can be associated with a high incidence of maternal apnea, requiring increased monitoring. Its transfer in utero to the fetus is minimal.
    2. Meperidine/pethidine/morphine should generally not be used except in small doses less than 1 hour or more than 4 hours prior to anticipated delivery because of greater incidence and duration of respiratory depression, cyanosis, and bradycardia in neonates.
    3. Nalbuphine, butorphanol, and pentazocine may be used for patients with certain opioid allergies or at increased risk of difficult airway management or respiratory depression. These medications may, however, interfere with fetal heart rate monitoring interpretation. Observe the mother and infant for psychotomimetic reactions (3%).
    4. Both the dosing (especially multiple doses) and the timing of parenteral analgesics may lead to greater neonatal effects. For example, fentanyl administration within 1 hour of delivery or meperidine/pethidine administration between 1 and 4 hours prior to delivery is associated with more profound neonatal effects.
    5. When a mother has received intravenous or intramuscular narcotics for labor, mother and infant should be given more skin-to-skin time to encourage early breastfeeding. (III)
  1. Although many studies have shown that epidural analgesia affects infant behavior, the effect of epidural analgesia on breastfeeding continues to be controversial.
    1. If epidural analgesia is chosen, methods that minimize the dose of medication and minimize motor block should be used. Doses of fentanyl >150 µg should be avoided. Longer durations and repeated administration of epidural analgesia should be avoided if possible, to minimize effect on labor outcomes that may secondarily affect breastfeeding. Combined spinal-epidural analgesia and patient-controlled epidural analgesia may be preferable. (I; II-2)
    2. When epidural analgesia has been used for labor, particular care to provide mothers with good breastfeeding support and close follow-up after postpartum hospitalization should be taken. (II-2)
  1. There are minimal data concerning the effects on the neonate of other labor anesthesia, including inhaled nitrous oxide, paracervical block, pudendal block, and local perineal anesthesia. These modalities do not usually expose the infant to significant quantities of medication. In some situations, these may serve as alternatives to intravenous narcotics or epidural analgesia for labor. Their use, however, is limited by several factors. These include lack of efficacy, technical difficulties in performing, and a high rate of complications.

Anesthesia for Cesarean Section

  1. Regional anesthesia (epidural or intrathecal/spinal) is preferred over general anesthesia. Separation of a mother and her infant should be minimized, and breastfeeding should be initiated as soon as feasible. In fact, the infant may go to the breast in the operating room during abdominal closure with assistance to support the infant on the mother's chest. If breastfeeding is initiated in the recovery room, there is the added advantage that the incision is often still under the influence of the anesthetic. (III)
  2. A mother who has had general anesthesia may breastfeed postoperatively as soon as she is alert enough to hold the infant and is not overly sedated. (III)

Postpartum Analgesia

  1. Non-opioid analgesics should generally be the first choice for pain management in breastfeeding postpartum women, as they do not impact maternal or infant alertness. (III)
    1. Acetaminophen/paracetamol and ibuprofen are safe and effective for analgesia in postpartum mothers.
    2. Ketorolac is commonly used for postpartum analgesia, especially after cesarean section, despite a Food and Drug Administration black box warning (in the United States) against the use of this medicine for breastfeeding women. Milk levels after oral administration are quite low, but levels have not been measured after parenteral administration.
    3. Diclofenac suppositories are available in some countries and commonly used for postpartum analgesia. Milk levels are extremely low.
    4. Cyclooxygenase-2 inhibitors such as celecoxib may have some theoretical advantages if maternal bleeding is a concern; this must be balanced with higher cost and possible cardiovascular risks, which should be minimal with short-term use in healthy young women.
  1. Both pain and opioid analgesia can have a negative impact on breastfeeding outcomes; thus mothers should be encouraged to control their pain with the lowest medication dose that is fully effective. Opioid analgesia postpartum may affect babies' alertness and suckling vigor. However, when maternal pain is adequately treated, breastfeeding outcomes improve. Mothers should be encouraged to adequately control their pain, especially after cesarean birth or severe perineal trauma requiring repair. (II-2)
    1. Parenteral medications (may be intravenous or intramuscular)
      1. Meperidine/pethidine should be avoided due to reported neonatal sedation when given to breastfeeding mothers postpartum, in addition to the concerns of cyanosis, bradycardia, and the risk of apnea that have been noted with intrapartum administration.
      2. The administration of moderate to low doses of intravenous or intramuscular morphine is preferred to meperidine/pethidine as passage to milk and oral bioavailability are least with this agent.
      3. When patient-controlled intravenous analgesia (PCA) is chosen after cesarean section, morphine or fentanyl is preferred over meperidine/pethidine.
      4. Levels of butorphanol in human milk have been reported with approximately 0.5% of the weight-adjusted maternal dose* transferred into human milk. These appear minimal and probably are of no concern to a breastfeeding neonate in the first week postpartum. The use of butorphanol during labor has been reported to produce sinusoidal fetal heart rate patterns and irritability in newborns.
      5. Levels of nalbuphine in human milk are quite low. In one study the levels of nalbuphine in milk average only 42 µg/L with an estimated weight-adjusted relative infant dose (RID) of 0.59%.
      6. Hydromorphone (approximately seven to 11 times as potent as morphine) is sometimes used for extreme pain in a PCA, intramuscularly, intravenously, or orally. Following a 2 mg intranasal dose, levels in milk were quite low with a weight-adjusted RID of about 0.67%. This correlates with about 2.2 µg/day via milk. This dose is probably too low to affect a breastfeeding infant, but this is a strong opioid, and some caution is recommended.
    1. Oral medications
      1. Hydrocodone has been used frequently in breastfeeding mothers worldwide. Less than 3.7% of the weight-adjusted maternal dose (RID) reaches the infant per day. Higher doses (10 mg of hydrocodone) and/or more frequent administration may lead to neonatal sedation and should be used with great caution.
      2. Recent cases have raised concern about the use of codeine. Some mothers may rapidly metabolize codeine to morphine, which can lead to toxic levels of morphine in the infant. Codeine should be used with caution, although it is probably safe in the majority of breastfeeding mothers.
      3. Several studies now suggest that oxycodone may be useful in some patients postpartum. Less than 3.5% of the weight-adjusted maternal dose (RID) transfers into human milk. Prolonged and frequent administration may lead to neonatal sedation. There is also the rare mother who is an ultrarapid metabolizer, whose babies are at higher risk for central nervous system depression [see Analgesics 1(i) below].
      4. Several recent studies of buprenorphine suggest that approximately 1.9% of the weight-adjusted maternal dose is transferred to the infant daily. Buprenorphine has a long half-life and should be used with some caution in infants who have not been previously exposed to the drug. Mothers treated continually for addiction may continue to breastfeed using this medication as long as the infant is tolerant to the current dose.
    1. Epidural/spinal medications
      1. Single-dose opioid medications (e.g., neuraxial morphine) should have minimal effects on breastfeeding because of egligible maternal plasma levels achieved. Extremely low doses of morphine are effective.
      2. Continuous post-cesarean epidural infusion may be an effective form of pain relief that minimizes opioid exposure. A randomized study that compared spinal anesthesia for elective cesarean with or without the use of postoperative extradural continuous bupivacaine found that the continuous group had lower pain scores and a higher volume of milk fed to their infants.

    *An important concept when discussing the risk of maternal medications to the breastfeeding infant is that of the relative infant dose. It is imperative to understand that this is a value that is calculated by dividing the infant's dose from the milk in mg/kg/day by the mother's dose in mg/kg/day. In this manner of calculation, a weight-normalized dose is determined that the baby may receive, which is more accurate than when one does not take the weight of the mother and the baby into account.

Anesthesia/Sedation for Surgery in Breastfeeding Mothers

  1. The implications of drugs used in anesthesia in postpartum mothers depend on numerous factors, including the age of the infant, the stability of the infant, the length of lactation, and the ability of the infant to clear small quantities of anesthetic medications. Anesthetic agents will have little or no effect on older infants but could potentially cause problems in newborn infants, particularly those who are premature or suffer from apnea. (III)
  2. Mothers with normal term or older infants can generally resume breastfeeding as soon as they are awake, stable, and alert. Resumption of normal mentation is a hallmark that these medications have redistributed from the plasma compartment (and thus generally the milk compartment) and entered adipose and muscle tissue where they are slowly released. The exception could be a drug that is highly lipid soluble, in which breast tissue may function as a fat compartment, acting as a drug reservoir. For women who undergo postpartum tubal ligation, interruption of breastfeeding is not indicated as the volume of colostrum is small; hence the dose to the infant is low as well. In addition, the levels of medication in the maternal plasma and milk are low once mothers resume normal mentation. For maternal safety, regional anesthesia is recommended for this procedure in preference to general anesthetic. (III)
  3. Mothers who have undergone dental extractions or other procedures requiring the use of single doses of medication for sedation and analgesia can breastfeed as soon as they are awake and stable. Although shorter-acting agents such as fentanyl and midazolam may be preferred, single doses of meperidine/pethidine or diazepam are unlikely to affect the breastfeeding infant. (III)
  4. Mothers who have undergone plastic surgery, such as liposuction, where large doses of local anesthetics (lidocaine/xylocaine or lignocaine) have been used should probably pump and discard their milk for 12 hours prior to resuming breastfeeding. (III)
  5. The maternal dose and the ability of the infant to clear small amounts of medications that can cause cardiorespiratory effects is of primary concern before returning to breastfeeding. Infants subject to apnea, hypotension, or hypotonia should probably be protected by a few more hours of interruption from breastfeeding (12–24 hours) prior to resuming nursing. (III)

Information About Specific Agents Used for Anesthesia and Analgesia

Anesthetic Agents

  1. Drugs used for anesthetic induction such as propofol, midazolam, etomidate, or thiopental enter the milk compartment only minimally, as they have extraordinarily brief plasma distribution phases (only minutes), and hence their transport to milk is low to nil.
  2. Little or nothing has been reported about the use of anesthetic gases in breastfeeding mothers. However, they too have brief plasma distribution phases, and milk levels are likely nil. A recent series of case reports suggests that xenon maintenance after propofol induction allows for breastfeeding immediately after surgery.
  3. The use of ketamine in breastfeeding mothers is unreported. Following the use of ketamine, many adult patients may exhibit dissociative anesthetic effects. This is often suppressed with the addition of midazolam or other benzodiazepines. The emergent reactions are apparently age-dependent and appear to occur more frequently in adults (30–50%) and less frequently in children (5–15%).
  4. For specific local anesthetics for epidural use (such as bupivacaine and ropivacaine), see general comments about epidural analgesia/anesthesia. These and other local anesthetics are poorly absorbed orally so should be safe in postpartum breastfeeding mothers. Milk levels of bupivacaine and ropivacaine are exceedingly low.

Analgesics

  1. Opioid analgesics
    1. Morphine is still considered an ideal analgesic for breastfeeding mothers due to its limited transport to milk and its poor oral bioavailability in infants.
    2. The transfer of meperidine/pethidine into breastmilk is low (1.7–3.5% of maternal weight-adjusted dose). However, meperidine/pethidine and its metabolite (normeperidine) are consistently associated with dose-related neonatal sedation. Transfer into milk and neonatal sedation have been documented for even up to 36 hours after a single dose. Meperidine/pethidine should be avoided during labor and in postpartum analgesia (except, perhaps, within 1 hour prior to delivery). Infants of mothers who have been exposed to repeated doses of meperidine/pethidine should be closely monitored for sedation, cyanosis, bradycardia, and possibly seizures.
    3. Although there are no published data on remifentanil, this esterase-metabolized opioid has a brief half-life even in infants (<10 minutes) and has been documented to produce no fetal sedation even in utero. Although its duration of action is limited, it could be used safely and indeed may be ideal in breastfeeding mothers for short painful procedures.
    4. Fentanyl levels in breastmilk have been studied and are extremely low after 2 hours and generally below the limit of detection.
    5. Sufentanil transfer into milk has not been published, but it should be similar to that of fentanyl.
    6. Nalbuphine and butorphanol levels in breastmilk are very low. At this time they would only be indicated in the specific situations mentioned previously. If these agents are used, observe the mother and infant for psychotomimetic reactions (3%).
    7. Hydrocodone has been used frequently in breastfeeding mothers. Occasional cases of neonatal sedation have been documented, but these are rare and generally dose related. Doses in breastfeeding mothers should be kept at the minimum necessary to control pain. Frequent dosing throughout the day may lead to sedative effects in the breastfed infant.
    8. A recent report of a neonatal death following the use of codeine suggests that the use of codeine in breastfeeding mothers should be monitored closely. Although rare, rapid metabolizers of codeine are known, and levels of morphine following the use of codeine may be significantly elevated thus putting the infant at risk. Use caution with codeine in breastfeeding mothers.
    9. Oxycodone levels in milk are known and average approximately 58 µg/L (range, 7–130 µg/L) (RID = 1.5– 3.5%). Oxycodone may not be significantly safer for the rare mother who is an ultrarapid metabolizer, as it is also a substrate for CYP2D6. A recent retrospective study showed that one in five breastfed infants with mothers medicated with oxycodone experienced central nervous system depression. The strong concordance between maternal and infant symptoms may be used to identify babies at higher risk. It is important to follow these infants carefully for drowsiness.
    10. Regardless of the opioid, always consider the dose used. Many mothers undergoing chronic pain therapy in various pain clinics may use exceedingly high doses of hydrocodone, oxycodone, methadone, and other opioid analgesics. Those infants of mothers with exceedingly high doses should be closely monitored for sedation and apnea. If the infants are exposed in utero, the risk, initially, is probably somewhat less because of tolerance of the infant.
  1. Non-steroidal anti-inflammatory drug analgesics

    Use of non-steroidal anti-inflammatory drugs (NSAIDs) alone after vaginal birth or in combination with opioids after cesarean birth can improve pain control by assisting with some of the pain due to uterine cramping. NSAIDs are generally safe for breastfeeding and can help minimize the total dose of opioid needed to control pain. (III)

    1. Ibuprofen is considered an ideal, moderately effective analgesic. Its transfer to milk is low to nil.
    2. Ketorolac is a potent analgesic in breastfeeding mothers and is increasingly popular when used postpartum. Its primary benefit is excellent analgesia, with no sedative properties. In addition, the transfer of ketorolac into milk is extremely low. However, its use in postsurgical patients with hemorrhage may be somewhat risky as it inhibits platelet function, although this is somewhat controversial. It should not be used in patients with a history of gastritis, aspirin allergy, or renal insufficiency. If there is no risk of hemorrhage, it carries few complications for breastfeeding mothers and their infants. However, the Food and Drug Administration now has a black box warning against use of ketorolac in breastfeeding women.
    3. Celecoxib transfer into milk is extraordinarily low (<0.3% of the weight-adjusted maternal dose). Its short-term use is safe.
    4. Naproxen transfer into milk is low, but gastrointestinal disturbances have been reported in some infants following prolonged therapy. Short-term use (1 week) is probably safe.

Definitions:

Levels of Evidence

I Evidence obtained from at least one properly randomized controlled trial

II-1 Evidence obtained from well-designed controlled trials without randomization

II-2 Evidence obtained from well-designed cohort or case-control analytic studies, preferably from more than one center or research group

II-3 Evidence obtained from multiple time series with or without the intervention. Dramatic results in uncontrolled experiments (such as the results of the introduction of penicillin treatment in the 1940s) could also be regarded as this type of evidence.

III Opinions of respected authorities, based on clinical experience, descriptive studies and case reports; or reports of expert committees

Clinical Algorithm(s)

None provided

Evidence Supporting the Recommendations

Type of Evidence Supporting the Recommendations

The type of supporting evidence is identified and graded for selected recommendation (see the "Major Recommendations" field).

Benefits/Harms of Implementing the Guideline Recommendations

Potential Benefits

Appropriate use of analgesics and anesthetics in breastfeeding mothers

Potential Harms
  • Labor pain may exceed a woman's ability to cope or be magnified by fear and anxiety. Suffering in labor may lead to dysfunctional labors, poorer psychologic outcomes, and increased risk of postpartum depression, all of which may have a negative effect on breastfeeding.
  • Depressed or delayed suckling, which can be caused by medications given to mothers, can lead to delayed or suppressed lactogenesis and risk of excess infant weight loss.
  • Treatment-related adverse events for the infant and the mother

Qualifying Statements

Qualifying Statements

A central goal of the Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient.

Implementation of the Guideline

Description of Implementation Strategy

An implementation strategy was not provided.

Implementation Tools
Foreign Language Translations
Resources
For information about availability, see the Availability of Companion Documents and Patient Resources fields below.

Institute of Medicine (IOM) National Healthcare Quality Report Categories

IOM Care Need
Getting Better
Staying Healthy
IOM Domain
Effectiveness
Patient-centeredness
Safety

Identifying Information and Availability

Bibliographic Source(s)
Montgomery A, Hale TW, The Academy of Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2012. Breastfeed Med. 2012 Dec;7:547-53. [59 references] PubMed External Web Site Policy
Adaptation

Not applicable: The guideline was not adapted from another source.

Date Released
2006 (revised 2012 Dec)
Guideline Developer(s)
Academy of Breastfeeding Medicine - Professional Association
Source(s) of Funding

Academy of Breastfeeding Medicine

This work was supported in part by a grant from the Maternal and Child Health Bureau, US Department of Health and Human Services.

Guideline Committee

Academy of Breastfeeding Medicine Protocol Committee

Composition of Group That Authored the Guideline

Committee Members: Kathleen A. Marinelli, M.D., FABM (Chairperson); Maya Bunik, M.D., MSPH, FABM (Co-Chairperson); Larry Noble, M.D., FABM (Translations Chairperson); Nancy Brent, M.D.; Amy E. Grawey, M.D.; Alison V. Holmes, M.D., M.P.H., FABM; Ruth A. Lawrence, M.D., FABM; Nancy G. Powers, M.D., FABM; Tomoko Seo, M.D., FABM; Julie Scott Taylor, M.D., M.Sc., FABM

Lead Contributors: Anne Montgomery; Thomas W. Hale

Financial Disclosures/Conflicts of Interest

Not stated

Guideline Status

This is the current release of the guideline.

This guideline updates a previous version: Montgomery A, Hale TW, Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #15: analgesia and anesthesia for the breastfeeding mother. Breastfeed Med 2006 Winter;1(4):271-7. [50 references]

Guideline Availability

Electronic copies: Available in Portable Document Format (PDF) from the Academy of Breastfeeding Medicine Web site External Web Site Policy.

Print copies: Available from the Academy of Breastfeeding Medicine, 140 Huguenot Street, 3rd floor, New Rochelle, New York 10801.

Availability of Companion Documents

The following is available:

Print copies: Available from the Academy of Breastfeeding Medicine, 140 Huguenot Street, 3rd floor, New Rochelle, New York 10801

Chinese and Korean translations of the original guideline document are available from the ABM Web site External Web Site Policy.

Patient Resources

None available

NGC Status

This NGC summary was completed by ECRI Institute on November 14, 2007. The information was verified by the guideline developer on October 31, 2008. This summary was updated by ECRI Institute on January 15, 2010 following the U.S. Food and Drug Administration (FDA) advisory on Voltaren Gel. This NGC summary was updated by ECRI Institute on February 19, 2013. This summary was updated by ECRI Institute on October 28, 2013 following the U.S. Food and Drug Administration advisory on Acetaminophen.

Copyright Statement

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions.

Single copies may be downloaded for personal use. Copyright permission to be requested for use of multiple copies by e-mailing requests to abm@bfmed.org. An official request form will be sent electronically to person requesting multiple copy use.

Disclaimer

NGC Disclaimer

The National Guideline Clearinghouse™ (NGC) does not develop, produce, approve, or endorse the guidelines represented on this site.

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