Practice parameter for the diagnosis and management of primary immunodeficiency (Algorithm 2)

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2-5. Pursue diagnosis of combined defect 2-11. Consider XLA, ARA, CVID 2-10. Consider CVID, SIGAD, IGGSD, HIM, SAD 2-9. Consider SIGAD, IGGSD, THI 2-7. Is B-cell count normal? 2-8. Consider complement or phagocyte defect, other conditions 2-6. Are immunoglobulins normal? 2-4. Is specific antibody production impaired? 2-1. Suspected antibody deficiency. Screening of humoral immune function. 2-3. Is cellular immunity abnormal? 2-2. Is there profound hypogammaglobulinemia? Source: Joint Council of Allergy, Asthma and Immunology. Practice parameter for the diagnosis and management of primary immunodeficiency. J Allergy Clin Immunol 2005 May;94:S1-63. All copyrights are reserved by the Joint Council of Allergy, Asthma and Immunology. Practice parameter for the diagnosis and management of primary immunodeficiency (Algorithm 2)